Using the ECM2 survey data on Ecuadorian migrants returning from Spain, we investigate the determinants of reintegration upon return. We study how the migration experience, but also the before- and after-migration characteristics, correlate with migrants’ outcomes upon return. We adopt a broad conception of reintegration, considering jointly labor market-related outcomes that proxy for structural reintegration and subjective indicators that provide insights on sociocultural reintegration. The determinants of these two types of outcomes appear to be different: reintegration indeed encompasses multiple dimensions which cannot be captured by a single indicator. Our results suggest that return assistance programs’ efficiency in helping reintegration could be improved by (i) targeting, ex-ante, returnees who plan to launch their own business, and, ex-post, the most vulnerable workers (women, older returnees, unemployed), and (ii) facilitating the labor market integration of foreign-educated returnees. They also call for further research to better understand the consequences of these programs.